Recent advancements in X-ray cluster Cosmology in preparation for eROSITA X-ray emission from the hot gas contained in galaxy clusters has long been established as a reliable method to selected large and clean samples of galaxy clusters. Utilising such samples to constrain the density and amplitude of fluctuation of matter in the Universe, as well as the evolution of Dark Energy, however, requires to overcome several observational challenges as well as to control several systematic effects. First, I review the established modelling framework to extract cosmological information from cluster catalogues and present the expected performance of eROSITA as a cosmological experiment. After that, I will present recent and ongoing efforts to control the dominant systematic effects plaguing cluster cosmology, ranging from mass calibration over optical confirmation and redshift estimation to the characterisation of the X-ray selection function. Finally, I will present novel techniques that allow one to empirically validate cluster cosmological results.